Neuroscience Graduate Program - Student Profile


Kara Fulton

Student Profile

Undergraduate Institution

University of Michigan

Research | Presentations & Posters | Publications | Accomplishments | Hobbies & Outside Interests

Research Description

I am investigating the subtype-specific connectivity of periglomerular cells (PGCs) in the mouse olfactory bulb (OB) using correlative serial block-face electron microscopy (SBEM).

By preserving extracellular space in acutely fixed sections (Pallotto and Watkins et al., 2015), I have developed a permeabilization-free immunohistochemistry protocol compatible with SBEM, which permits deep antibody penetration and preserves ultrastructure. SBEM, in combination with immunohistochemistry in the same piece of tissue, allows us to correlate the morphological and physiological properties of neurons through a dense reconstruction of the synaptic connectivity. I am utilizing this approach to investigate the differences in synaptic connectivity between neurochemically-distinct PGC subtypes and OB principal neurons, mitral (MCs) and tufted cells (TCs). Since the functional roles of PGC subtypes remain unknown due to a lack of knowledge about how they connect to MCs and TCs, understanding the connectivity will be important for future investigations into subtype-specific involvement in odor processing.

Presentations and Posters

Fulton KA, Briggman KL. Correlative serial block-face scanning electron microscopy in the mouse olfactory bulb glomerulus. NIH Graduate Student Seminar Series, May 30, 2017, Bethesda, MD.

Fulton KA, Briggman KL. Correlative serial block-face scanning electron microscopy in the mouse olfactory bulb glomerulus. Poster Presentation at the annual AChemS Conference, April 27, 2017, Bonita Springs, FL.

Fulton KA, Briggman KL. Correlative serial block-face scanning electron microscopy in the mouse olfactory bulb glomerulus. Poster Presentation at the HHMI Connectomics Meeting, April 10, 2017, Berlin, Germany.

Fulton KA, Briggman KL. Permeabilization-free antibody labeling protocol for correlative serial block-face scanning electron microscopy. Poster Presentation at the Janelia Frontiers in Imaging Science Conference, April 3, 2017, Ashburn, VA.

Fulton KA, Briggman KL. Permeabilization-free antibody labeling protocol for correlative serial block-face scanning electron microscopy. Poster Presentation at the annual NINDS Intramural Retreat, June 2, 2016, Bethesda, MD.

Fulton KA, Briggman KL. Detergent-free antibody labeling protocol for correlative serial block-face scanning electron microscopy. Janelia High Resolution Circuit Reconstruction Conference, April 11, 2016, Ashburn, VA.

Fulton KA, Briggman KL. Permeabilization-free antibody labeling protocol for correlative serial block-face scanning electron microscopy. Poster presentation at the annual NIH Graduate Student Symposium, January 12, 2016, Bethesda, MD.

Fulton KA, Briggman KL. The functional and synaptic connectivity of periglomerular interneurons in the mouse olfactory bulb. Poster presentation at the annual NINDS Intramural Retreat, May 27, 2015, Bethesda, MD.

Fulton KA, Briggman KL. The functional and synaptic connectivity among periglomerular interneurons and mitral and tufted cells in the mouse olfactory bulb. Poster presentation at the annual NIH Graduate Student Symposium, January 13, 2015, Bethesda, MD.

Winer KK, Fulton KA, Albert PS, Nixon-Jones D, Cutler GB. Twice-daily subcutaneous injections vs. pump delivery of PTH 1-34 in the treatment of children with severe congenital hypoparathyroidism. Refereed late-breaking poster presentation at The Endocrine Society Annual Meeting, June 16, 2013, San Francisco, CA.

Fulton KA, Liu D, Haynie DL, Albert PS. Zero-inflation in clustered binary response data: mixed model and estimating equation approaches. Poster presentation at the Annual Meeting of the Eastern North American Region of the International Biometric Society, March 10, 2013, Orlando, FL.

Publications

Wheeler AR, Fulton KA, Gaudette JE, Simmons RA, Matsuo I, Simmons JA. Echolocating big brown bats, Eptesicus fuscus, modulate pulse intervals to overcome range ambiguity in cluttered surroundings. Frontiers in Behavioral Neuroscience 10:125, (2016).

Fulton KA*, Liu D*, Haynie DL, Albert PS. Mixed model and estimating equation approaches for zero-inflation in clustered binary response data with application to a dating violence study. The Annals of Applied Statistics 9:1, 275-299 (2015).*Co-first authors.

Winer KK, Fulton KA, Albert PS, Cutler GB. Effects of pump versus twice-daily injection delivery of synthetic parathyroid hormone 1-34 in children with severe congenital hypoparathyroidism. The Journal of Pediatrics 165:3, 556-563 (2014).

Fulton KA and Briggman KL. Detergent-free antibody labeling protocol for correlative serial block-face scanning electron microscopy. In preparation.

Accomplishments

LEADERSHIP & TEACHING EXPERIENCE:
-Founder of Graduate Students Mentor Lunch Series, 2016-2017
-Community Service Chair for Graduate Student Council, 2017
-Co-Chair for Graduate Student Council, 2015-2016
-Committee for Graduate Student Retreat, August 2016
-Secretary for Graduate Student Council, 201-2015
-Instructor for FAES course BIOL262: Research Tools for Studying Diseases, Spring 2015
-NIH Summer Intern Journal Club Leader, Summer 2014
-Brown University Graduate-Undergraduate Mentor Initiative Program, 2013-2014

FELLOWSHIPS & AWARDS:
-Summer research mentor award, 2017
-Travel award to the AChemS Conference, 2017
-First place for poster presentation at NINDS Intramural Retreat, NIH, 2015
-Pre-doctoral Intramural Research Training Award, NIH, 2013-Present
-Post-baccalaureate Intramural Research Training Award, NIH, 2011-2013
-Research Experience for Undergraduates Fellowship, National Science Foundation, 2010
-Dominic Tomasi Scholarship Fund, University of Michigan Alumni Association, 2007-2010

Hobbies and Outside Interests