Neuroscience Graduate Program - Student Profile


Gabriela Manzano

Student Profile

I received a B.S. in Molecular and Cellular Biology from the University of Puerto Rico - Rio Piedras Campus. As an undergraduate I worked in Dr. Gregory J. Quirk lab investigating the role of the infralimbic prefrontal cortex on conditioned fear extinction and memory recall. As a graduate student in Dr. Kevin G. Bath lab I study the developmental consequences of early life stress in a mouse model.

Undergraduate Institution

University Of Puerto Rico - Rio Piedras

Research | Presentations & Posters | Publications | Accomplishments | Hobbies & Outside Interests

Research Description

Early life stress (ELS), can significantly impact neuronal development, with implications for cognitive and emotional development. While a great deal of work has focused on the linkage between ELS and affective development, less is known with regard to the mechanisms underlying the relationship between ELS and disturbances in memory function. Knowing when and how ELS affects the development of memory systems will be critical for identifying the impact of memory on behavioral development, and elucidating the mechanisms by which childhood experiences alter neuronal circuits. To study the effects of ELS, we use mice exposed to maternal bedding restriction stress (from P4-P11) and control reared animals. To assess possible mechanisms and effects of ELS on specific neuronal populations and brain structures I use a combination of molecular, systems, and behavioral techniques.

Presentations and Posters

2015: Manzano-Nieves G, Bath KG (2015) Early life stress alters the development of the fear circuit and fear learning in mice. Presented at Neuroscience 2015 sponsored by the Society for Neuroscience

2015: Bath KG, Manzano-Nieves G, Goodwill H (2015) Early life stress accelerates behavioral and neural maturation of the hippocampus. Presented at Neuroscience 2015 sponsored by the Society for Neuroscience

2015: Huntzicker KB, Manzano-Nieves G, Bath KG (2015) BDNF: A potential driver of early life stress associated accelerated neurobehavioral development. Presented at Brown Undergraduate Research Symposium

2015: Manzano-Nieves G, Bath KG (2015) The effect of early life adversity on emotional memories during development. Presented at the International Society for Developmental Psychobiology

2014: Manzano-Nieves G, Bath KG (2014) Early Life Stress impairment of select hippocampus dependent functions is sex and age specific. Presented at the International Society for Developmental Psychobiology

2014: Bath KG, Manzano-Nieves G (2014) Early life stress accelerates neurobehavioral development. Presented at the International Society for Developmental Psychobiology

2014: Lee HI, Manzano-Nieves G, Bath KG (2014) Effects of fragmented maternal care on anxiety and stress responding in mice. Presented at Brown Undergraduate Research Symposium

2013: Manzano-Nieves G, Do Monte FHM, Quirk GJ (2013) Extinguishing Fear: Revisiting the Infralimbic Cortex with an Optogenetic Approach. Presented at Neuroscience 2013 sponsored by the Society for Neuroscience

2013: Do Monte FHM, QuiƱones-Laracuente K, Manzano-Nieves G, Quirk GJ (2013) Optogenetic silencing of prelimbic inputs to paraventricula thalamus impairs long-term fear retrieval. Presented at Neuroscience 2013 sponsored by the Society for Neuroscience

2012: Manzano-Nieves G, Do Monte FHM, Quirk GJ (2012) Extinguishing Fear: Revisiting the Infralimbic Cortex with an Optogenetic Approach. Presented at the Annual Biomedical Research Conference for Minority Students

Publications

Do-Monte FH*, Manzano-Nieves G*, QuiƱones-Laracuente K, Ramos-Medina L, Quirk GJ (2015) Revisiting the Role of Infralimbic Cortex in Fear Extinction with Optogenetics . J. Neuroscience

*Equal Contributors

Accomplishments

2015: Awarded travel award to the International Society of Developmental Psychobiology annual conference

2015: Awarded a Graduate Research Fellowship Program grant by the United States National Science Foundation

2014: Awarded travel award to the International Society of Developmental Psychobiology annual conference

2013-2015: Awarded National Institute of Health (NIH) research training fellowship grant

2012-2013: Awarded undergraduate training grant through the Research Initiative for Scientific Enhancement (RISE) program sponsored by the NIH

2012: Honored and awarded legislative recognition for my academic and civil work by the Caguas, P.R. municipal legislature

2012: Awarded poster presentation prize in the field of Neuroscience for; Manzano-Nieves G, Do Monte FHM, Quirk GJ (2012) Extinguishing Fear: Revisiting the Infralimbic Cortex with an Optogenetic Approach at the Annual Biomedical Research Conference for Minority Students (ABRCMS)

2012: Awarded poster presentation prize for interdisciplinary work for; Manzano-Nieves G, Do Monte FHM, Quirk GJ (2012) Extinguishing Fear: Revisiting the Infralimbic Cortex with an Optogenetic Approach at ABRCMS

2012, 2013: Awarded Conte Center for Research in Obsessive Compulsive Disorder 8-week undergraduate training program

2011: Awarded travel award to the Caribbean HIV Conference: Strengthening Evidence to Achieve Sustainable Action. Sponsored by NIH, OAR, DHHS, University of Puerto Rico, and the Commonwealth of the Bahamas

Hobbies and Outside Interests