Jennifer Sanders, Ph.D.Edit My Page
My laboratory focuses on understanding the growth and proliferation of liver progenitor cells. These cells are capable of restoring liver function upon transplantation to an injured liver. By studying these cells, we hope to gain insight into the mechanisms that promote or inhibit liver stem cell engraftment and expansion. This knowledge could lead to new methods to improve the clinical success of liver cell transplantation and provide insight into the development of liver cancer.
Honorable Mention, National Science Foundation Graduate Research Fellowship, 2001
NIH Graduate Training Fellowship
NIH Postdoctoral Training Fellowship, 2005
Member, American Association for Cancer Research, 2003-Present
Member, American Society for Biochemistry and Molecular Biology, 2005-Present
Member, American Society for Investigate Pathology
R01 HD 24455 Gruppuso (PI) 04/01/1989 to 03/31/2017
Novel Approaches to Understanding the Nutrient Regulation of Fetal Somatic Growth
This project focuses on growth promoting signal transduction mechanisms in late gestation fetal liver
development. The present cycle focuses on the role of mTOR in ribosomal biogenesis and on the
proteomic analysis of PP6, a Ser/Thr protein phosphatase that may be a component of the mTOR
pathways, and on the mechanisms by which mTOR regulates cell cycle progression in hepatocytes.
P20 RR017695-06A2 Hixson (PI) 07/10/2009 to 04/30/2014
COBRE Center for Cancer Research Development
Growth Regulation of Liver Progenitor Cells
Role: Project 5 PI
This project focuses on the signal transduction pathways that regulate the growth and
proliferation of cells capable of repopulating an injured adult liver. These studies will focus on
mitogenic signaling pathways found to be differentially regulated in fetal and adult liver.
P20 ES018169-01 Boekelheide (PI) 2/15/2010-2/14/2013
NIH (NIEHS) & EPA
Formative Center for the Evaluation of Enivronmental Impacts on Fetal Development
Liver and the Metabolic Syndrome
Role: Project 1 Co-Investigator
This project focuses on the development of a xenotranplantation model where human fetal liver is
transplanted into immunodeficient rats. This model will be used to assess the effect of arsenic on the
human fetal liver epigenome.