Recombinant human biglycan (rhBGN) treatment upredulates utrophin in mdx mice. Amenta, 2007. Utrophin immunostaining of sectioned quadriceps muscle from P33 mdx littermate mice that received a single IP injections of either rhBGN or vehicle at P19. Shown is a region of peripheral-nucleated (i.e. non-regenerated) myofibers. rhBGN treatment increased sarcolemmal utrophin levels in these fibers. Scale bar = 25µm.