:: DEPARTMENT OF NEUROSCIENCE :: BROWN UNIVERSITY ::

Ph.D., Brown University
Henry Merritt Wriston Professor
Department of Neuroscience
552 Sidney Frank Hall of Life Sciences
Tel: (401) 863-2701
Email: John_Donoghue@Brown.edu
Go to lab web page

Our lab investigates how the brain turns thought into voluntary behaviors. At the core of this problem is understanding higher level neural coding- how populations of neurons represent complex information. To study neural coding we are developing novel multielectrode recording arrays suitable for chronic implantation in the cerebral cortex. We are using these multielectrode arrays to examine the coding of goal directed reaching by ensembles of cerebral cortical neurons and to examine how ensembles change when a new motor skill is learned. Our laboratory works closely with several other Brown Brain Science faculty members to develop and test theories of higher order representation and to generate new mathematical tools to examine neural codes. We are also applying our knowledge of neural codes for movement to build brain computer interfaces. These devices can potentially be used a neural prosthetic to restore movement to paralyzed humans.

Truccolo W, Friehs GM, Donoghue JP, Hochberg LR. Primary motor cortex tuning to intended movement kinematics in humans with tetraplegia. J Neurosci. 2008 Jan 30;28(5):1163-78.

Truccolo, W. & Donoghue, J.P., (2007) Nonparametric Modeling of Neural Point Processes via Stochastic Gradient Boosting Regression. Neural Computation, 19, 672-705.

Hochberg, L.R., Serruya, M.D, Friehs, G.M, Mukand, J.A., Saleh, M, Caplan, A.H., Branner, A., Chen, D., Penn, R.D., and Donoghue, J.P. (2006) Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature, 442, 164-171 (13 July 2006) Nature issue: http://www.nature.com/nature/journal/v442/n7099/index.html Web Focus on Brain-Machine Interfaces: http://www.nature.com/nature/focus/brain/index.html

Wu, W., Gao, Y., Bienenstock, E., Donoghue, J. P., Black, M.J. (2006) Bayesian population decoding of motor cortical activity using a Kalman filter Neural Computation: 2006; 18(1):80-118.

Aaron, R.K., H. Herr, D. McK. Ciombor, L. Hochberg, J. Donoghue, C. Briant, J. Morgan, M. Ehrlich. Horizons in prosthetic development for restoration of limb function. J Am Acad Orthop Surg. 14: S198-204: 2006

Kim, S.-P., Wood, F., Fellows, M., Donoghue, J. P., Black, M. J. (2006) Statistical analysis of the non-stationarity of neural population codes. BioRob 2006, The first IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, 295-299, Piza, Italy, February 2006.

Kübler, A., Mushahwar, V. K., Hochberg, L. R., and Donoghue, J. P. (2006) BCI Meeting 2005--Workshop on Clinical Issues and Applications. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2006 June, 14(2): 131-134.

Shoham, S., Paninski, L.M., Fellows, M.R., Hatsopoulos, N.G., Donoghue, J.P., Normann, R.A. (2005). Statistical Encoding Model for a Primary Motor Cortical Brain-Machine Interface. IEEE Transactions on Biomedical Engineering, 52(7): 1312-1322

Suner, S., Fellows, M. R., Vargas-Irwin, C., Nakata, G. K., Donoghue, J. P. (2005) Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex. IEEE Transactions in Neural Systems and Rehabilitation Engineering, vol. 13, No. 4, 524-541.

Truccolo, W., Eden, U. T., Fellows, M. R., Donoghue, J. P., Brown, E. N. (2005) A point process framework for relating neural spiking activity to spiking history, neural ensemble and extrinsic covariate effects. J. Neurophysiology 93(2): 1074-1089.

Song, Y. K., Patterson, W. R., Bull, C. W., Beals, J., Hwang, N., Deangelis, A. P., Lay, C., McKay, J. L., Nurmikko, A. V., Fellows, M. R., Simeral, J. D., Donoghue, J. P., Connors, B. W. (2004) Development of a chipscale integrated microelectrode/microelectronic device for brain implantable neuroengineering applications. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2005 June; 13(2): 220-226.

Paninski, L., Fellows, M.R., Hatsopoulos, N.G., and Donoghue, J.P. (2004) Spatiotemporal tuning of motor cortical neurons for hand position and velocity. Journal of Neurophysiology 91(1): 515-32.

Paninski, L., Shoham, S., Fellows, M., Hatsopoulos, N., & Donoghue, J. (2004). Superlinear population encoding of dynamic hand trajectory in primary motor cortex. Journal of Neuroscience, 24(39): 8551-8561.

Wood, F.D., Black, M. J., Vargas-Irwin, C., Fellows, M., Donoghue, J. P. (2004) On the variability of manual spike sorting.. IEEE Transactions on Biomedical Engineering 51 (6): 912-918 June 2004.

Eden, U. T., Truccolo, W., Fellows, M. R., Donoghue, J. P., Brown, E. N. (2004) Reconstruction of hand movement trajectories from a dynamic ensemble of spiking motor cortical neurons. Proceedings of the 26th Annual International Conference of the IEEE EMBS, San Francisco, CA.

Wu, W., Black, M.J., Mumford, D., Gao, Y., Bienenstock, E., Donoghue, J. P. (2004) Modeling and decoding motor cortical activity using a switching Kalman filter. IEEE Transactions on Biomedical Engineering 51 (6): 933-942 June 2004.

Friehs, G. M., Zerris, V. A., Ojakangas, C. L., Fellows, M. R., Donoghue, J. P. (2004) Brain-machine and brain-computer interfaces. Stroke 2004 November; 35(11 Supplement 1); 2702-2705. Epub 2004 Oct 14. Review.

Wu, W., Black, M. J., Mumford, D., Gao, Y., Bienenstock, E., Donoghue, J. P. (2003) A switching Kalman filter model for the motor cortical coding of hand motion. to appear: Proc. IEEE EMBS, Cancun, Sept. 2003.

Gao, Y., Black, M.J., Bienenstock, E., Wu, W., and Donoghue, J.P. (2003) A quantitative comparison of linear and non-linear models of motor cortical activity for the encoding and decoding of arm motions. 1st International IEEE/EMBS Conference on Neural Engineering, Capri, Italy, March 20-22, 2003, 189-192.

Hatsopoulos, N.G., Paninski, L., Donoghue, J.P. (2003) Sequential movement representations based on correlated neuronal activity. Experimental Brain Research 14(4)9:478-86 Apr 2003.

Serruya, M., Hatsopoulos, N. Fellows, M. Paninski, L, and Donoghue, J. (2003) Robustness of neuroprosthetic decoding algorithms. Biological Cybernetics 88 (3): 219-228 March 2003. Springerlink to PDF The original publication is available at http://link.springer-ny.com.

Serruya, M.D., Hatsopoulos, N.G., Paninski, L., Fellows, M.R., and Donoghue, J.P. (2002) Instant neural control of a movement signal. Nature 416:141-2.

Oram, M.W., Hatsopoulos, N.G., Richmond, B.J., and Donoghue, J.P. (2001) Excess synchrony in motor cortical neurons provides redundant direction information with that from coarse temporal measures. Journal of Neurophysiology 86(4):1700-16.

Jerome N. Sanes and John P. Donoghue Plasticity and Primary Motor Cortex. Annu. Rev. Neurosci. 2000 23: 393-415.

Rioult-Pedotti, M.S., Friedman, D., and Donoghue, J.P. (2000) Learning-induced LTP in neocortex. Science 2000 October 20, 290(5491):533-6 (in Reports).

For more publications please visit the Donoghue lab web page