Select publications:
Jakubek LM, Marangoudakis S, Raingo J, Liu X, Lipscombe D, Hurt RH. (2009)
The inhibition of neuronal calcium ion channels by trace levels of yttrium released from carbon nanotubes.
Biomaterials Aug 19. [Epub ahead of print]. [PubMed]
Lipscombe D, Pan JQ. (2009)
Tripping the HCN breaker.
Neuron Jun 25;62(6):747-50. [PubMed]
Fairbrother W, Lipscombe D. (2009)
Repressing the neuron within.
Bioessays Jan;30(1):1-4. [PubMed]
Diane Lipscombe, Summer E. Allen, Annette C. Gray, Spiro Marangoudakis, and Jesica Raingo (2009)
Alternative splicing of neuronal CaV2 calcium channels.
Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels Eds: Leonard K. Kaczmarek and Valentin K. Gribkoff. ISBN: 978-0-471-93013-6, 475 pages. [Wiley Publishing Group]
Lipscombe, D & Raingo, J. (2007)
Alternative Splicing Matters: N-type Calcium Channels in Nociceptors.
Channels Jul-Aug 1(4):225-7. [PubMed]
Altier C, Dale CS, Kisilevsky AE, Chapman K, Castiglioni AJ, Matthews EA, Evans RM, Dickenson AH, Lipscombe D, Vergnolle N, Zamponi GW. (2007)
Differential role of N-type calcium channel splice isoforms in pain.
J Neurosci. Jun 13;27(24):6363-73. [PubMed]
Gray AC, Raingo J, Lipscombe D. (2007)
Neuronal calcium channels: splicing for optimal performance.
Cell Calcium Oct-Nov;42(4-5):409-17. [PubMed]
Raingo J, Castiglioni AJ, Lipscombe D. (2007)
Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptors.
Nat Neurosci. Mar;10(3):285-92. [PubMed]
Castiglioni AJ, Raingo J, Lipscombe D. (2006)
Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels.
J Physiol. 1;576(Pt 1):119-34. [PubMed]
Lipscombe D, Raingo J. (2006)
Internalizing channels: a mechanism to control pain?
Nat Neurosci. Jan;9(1):8-10. [PubMed]
Helton TD, Xu W, Lipscombe D. (2005)
Neuronal L-type calcium channels open quickly and are inhibited slowly.
J Neurosci. 2;25(44):10247-51. [PubMed]
Lipscombe, D. (2005)
Neuronal proteins custom designed by alternative splicing.
Curr Opin Neurobiol 15(3):358-63. [PubMed]
Lipscombe D, Helton TD, Xu W. (2004)
L-type calcium channels: the low down.
J Neurophysiol. 92(5):2633-41.
[PubMed]
Lin, Y., McDonough, S.I., Lipscombe, D. (2004)
Alternative splicing in the voltage-sensing region of N-Type CaV2.2 channels modulates channel kinetics.
J Neurophysiol. 92:2820-2830.
[PubMed]
Thaler, C., Gray, A.C., Lipscombe, D. (2004)
Cumulative inactivation of N-type Cav2.2 calcium channels modified by alternative splicing.
Proceedings of the National Academy of Science, USA. 101:5675-5679.
[PubMed]
Bell, T.J., Thaler, C., Castiglioni, A.J., Helton, T.D., Lipscombe, D. (2004)
Cell-specific alternative splicing increases calcium channel current density in the pain pathway.
Neuron. 41:127-138.
[PubMed]
Lipscombe, D & Castiglioni, AJ(2004)
Alternative splicing in voltage-gated calcium channels.
Calcium Channel Pharmacology Kluwer/ Academic/ Plenum Publishing. Ed. Stefan I McDonough.
[PubMed]
Lipscombe D, Pan JQ, Gray AC. (2002)
Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Ca(v)alpha1.
Mol Neurobiol. 26(1):21-44.
[PubMed]
Lipscombe D. (2002)
L-type calcium channels: highs and new lows.
Circ Res. 90(9):933-5.
[PubMed]
Xu W, Lipscombe D.(2001)
Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines.
J Neurosci. 21(16):5944-51.
[PubMed]
Lipscombe, D. (2001)
"Ion channels", The Encyclopedia of Life Sciences, Macmillan Press.
Pan JQ, Lipscombe D.(2000)
Alternative splicing in the cytoplasmic II-III loop of the N-type Ca channel alpha 1B subunit: functional differences are beta subunit-specific.
J Neurosci. 20(13):4769-75.
[PubMed]
Schorge S, Gupta S, Lin Z, McEnery MW, Lipscombe D.(1999)
Calcium channel activation stabilizes a neuronal calcium channel mRNA.
Nat Neurosci. 2(9):785-90.
[PubMed]
Lin Z, Lin Y, Schorge S, Pan JQ, Beierlein M, Lipscombe D.(1999)
Alternative splicing of a short cassette exon in alpha1B generates functionally distinct N-type calcium channels in central and peripheral neurons.
J Neurosci. 1;19(13):5322-31.
[PubMed]
Lin Z, Haus S, Edgerton J, Lipscombe D.(1997)
Identification of functionally distinct isoforms of the N-type Ca2+ channel in rat sympathetic ganglia and brain.
Neuron. 18(1):153-66.
[PubMed]
Lin Z, Harris C, Lipscombe D.(1996)
The molecular identity of Ca channel alpha 1-subunits expressed in rat sympathetic neurons.
J Mol Neurosci. 7(4):257-67.
[PubMed]